William Zeisler was a Little Rock, Arkansas, soda water manufacturer from the 1870s to the 1920s.
Zeisler began making and bottling soda water in 1871 at 311 East Third Street. Around 1880 he moved his soda bottling works to the alley behind a house at 413 East Third Street. Son William Zeisler Jr. and brother Adam Zeisler also worked for the soda works.
William Zeisler lived at 223 Rock Street, and later at 2117 Cumberland Street. He died in 1929.